Despite significant progress, cancer continues to be the second-leading cause of death in the U.S. More than 2 million new cases of cancer are likely to be diagnosed in the U.S. this year. More than 618,000 deaths are expected from cancer in 2025.
There's also a huge financial cost that's growing rapidly. In 2020, treating cancer in the U.S. cost roughly $200 billion. By 2030, the total is projected to increase to more than $245 billion.

But with every problem comes an opportunity -- in this case, a massive opportunity to put your dollars to work to help the large and small companies that are developing new ways of diagnosing and treating cancer. Here's what you need to know about some of the leading cancer-focused healthcare stocks that investors should consider.
Top cancer stocks for 2026
Cancer stocks include drugmakers that focus on developing cancer therapies and companies that develop products used in screening for cancer. Some of these stocks are highly volatile, such as early-stage biotech stocks. Others, though, are more established and less risky. Here are four top cancer stocks to consider that include both small and large companies:
| Name and ticker | Current price | Market cap | Industry |
|---|---|---|---|
| Guardant Health (NASDAQ:GH) | $92.24 | $12.3 billion | Healthcare Providers and Services |
| Illumina (NASDAQ:ILMN) | $132.11 | $20.6 billion | Life Sciences Tools and Services |
| Pfizer (NYSE:PFE) | $27.40 | $157.2 billion | Pharmaceuticals |
| BeOne Medicines Ag (NASDAQ:ONC) | $310.76 | $35.1 billion | Biotechnology |
1. Guardant Health

NASDAQ: GH
Key Data Points
2. Illumina

NASDAQ: ILMN
Key Data Points

NYSE: PFE
Key Data Points

NASDAQ: ONC
Key Data Points
BeOne Medicines, formerly known as BeiGene, markets blood cancer drug Brukinsa and esophageal cancer drug Tevimbra in the U.S. and other countries. Brukinsa is the company's flagship product, with sales continuing to grow strongly.
Another cancer therapy could soon be added to BeOne's lineup. The U.S. Food and Drug Administration (FDA) is scheduled to make an approval decision as a treatment for relapsed or refractory mantle cell lymphoma in the first half of 2026.
BeOne could possibly have yet another approval on the way as well. The drugmaker hopes to file for accelerated approval in the second half of 2026 for BGB-16673, a Bruton tyrosine kinase (BTK) chimeric degradation compound (CDAC), pending positive results from a Phase 2 study.
How to invest in cancer stocks
Follow these steps to invest in cancer stocks:
- Open your brokerage app: Log in to your brokerage account where you handle your investments.
- Search for the stock: Enter the ticker or company name into the search bar to bring up the stock's trading page.
- Decide how many shares to buy: Consider your investment goals and how much of your portfolio you want to allocate to this stock.
- Select order type: Choose between a market order to buy at the current price or a limit order to specify the maximum price you're willing to pay.
- Submit your order: Confirm the details and submit your buy order.
- Review your purchase: Check your portfolio to ensure your order was filled as expected and adjust your investment strategy accordingly.
Tips for investing in cancer stocks
Below are some practical strategies and actionable tips for investing in cancer stocks:
- Diversify your holdings. You shouldn't have too great a percentage of your overall portfolio invested in any one area.
- Evaluate the pipelines of any cancer stocks you're considering. Focus more on companies with programs in late-stage testing to reduce risk.
- Review companies' intellectual property protection. Some could face patent expirations in the near term that could reduce their growth.
- Thoroughly examine the financial position of any cancer stock on your radar screen. For established companies, check out their returns on equity (ROE). An ROE of 15% or more is preferred. For clinical-stage companies, ensure they have enough cash to fund operations without diluting the value of existing shares through equity offerings.
Why invest in cancer stocks?
The main purpose of investing in any stock is to generate positive returns. Many cancer stocks offer an opportunity to achieve this goal.
Millions of people across the world have cancer. Millions more are diagnosed with cancer each year. Companies that develop effective cancer diagnostic tools and therapies can generate significant revenue and profits. Their stocks can deliver attractive returns over the long term.
Benefits and risks of investing in cancer stocks
The benefits of investing in cancer stocks include:
- Potential for significant long-term returns.
- Relatively recession-resistant investment alternatives.
- Allows investing in a way that could help save lives.
However, there are also risks of investing in cancer stocks, such as:
- Volatility.
- The potential for losses, especially with clinical-stage drugmakers.
How to evaluate cancer stocks
Factors to consider when evaluating cancer stocks include:
- Financial strength.
- Look for stocks with a return on equity of 15% or more.
- Look for low debt levels and debt ratios using the company's balance sheet.
- Valuation.
- Compare the company's price-to-earnings (P/E) ratio against the earnings multiples of peers.
- Growth prospects.
- Check out Wall Street analysts' growth projections.
- Review sales growth trends of the company's products versus rival products.
- Review the company's development pipeline.
Future outlook for cancer stocks
Trends and factors affecting the outlook for cancer stocks include:
- Artificial intelligence (AI) will become increasingly important in drug discovery and development, as well as cancer screening.
- Precision medicine, which involves using a patient's genetic profile, environment, and lifestyle to develop therapies, will almost certainly become more prevalent.
- Liquid biopsies will be more widely accepted and increasingly used in early cancer detection and disease monitoring.
- Growth is likely to be driven in part by aging demographics in the U.S. and other countries.
Related investing topics
FAQ
Cancer stocks FAQ
About the Author
Keith Speights has positions in Bristol Myers Squibb and Pfizer. The Motley Fool has positions in and recommends Amgen, Bristol Myers Squibb, Guardant Health, Merck, Pfizer, and Summit Therapeutics. The Motley Fool recommends Grail, Illumina, and Johnson & Johnson. The Motley Fool has a disclosure policy.







